Biological Computer Modeling / Biological Computer Simulation
Gelare Valizadeh; Fateme Fatemi; Mahmoud Shahabadi; Mohammad Ali Oghabian; Majid Pouladian
Volume 8, Issue 2 , June 2014, , Pages 125-133
Abstract
MTDDS is an innovative treatment modality to completely tumor remission with no negative side effect. In this method functionalize magnetic nanoparticles are designed as the drug carrier to get the specific target in the body. Anticancer agents are bounded to magnetite nanoparticles with biocompatible ...
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MTDDS is an innovative treatment modality to completely tumor remission with no negative side effect. In this method functionalize magnetic nanoparticles are designed as the drug carrier to get the specific target in the body. Anticancer agents are bounded to magnetite nanoparticles with biocompatible starch coating suspended in the fluid. Now if they are injected intra-arterially near the target volume, they would be trapped at the target region via a local applied magnetic field with the high gradient near the target site. In this paper we have evaluated some nanoparticle trajectories with different size in order to evaluate the effect of the size on the efficiency of the magnetic drug targeting system.
Tissue Engineering
Jafar Ai; Saeed Sarkar; Mohammad Ali Oghabian
Volume 4, Issue 2 , June 2010, , Pages 161-166
Abstract
Various reviews have shown that strong electromagnetic fields have negative effects on human health. This study focused on the effect of MRI radiation on liver functional test histometery of liver in adult male rats. For this purpose, we used an MRI device that could produce 1.5 T electromagnetic radiations, ...
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Various reviews have shown that strong electromagnetic fields have negative effects on human health. This study focused on the effect of MRI radiation on liver functional test histometery of liver in adult male rats. For this purpose, we used an MRI device that could produce 1.5 T electromagnetic radiations, and chose 22 Wistar rats as laboratory animal models. Rats were divided into two equal groups. The first group exposed to 1.5T electromagnetic radiation and RF radiation during a 30- minute MRI scan as experimental group. The control group experienced 1.5T electromagnetic radiation exposure without RF radiation by the same MRI device. The rats were anesthetized and blood samples were obtained from cardiac chambers to measure the serum levels of LDL, HDL, ALT, AST, ALP, total cholesterol, total protein, albumin, total billirobin, and direct bilirobin. Livers were then removed and the specimens fixed. Serial sections (5 μm thick) were prepared from livers and the diameter of hepatocytes and their nuclei were measured. The findings of the present study indicate that, there was a significant increase (P<0.5) in amount of HDL, ALT, AST, ALP, total billirobin, direct bilirobin and there was a significant decrease (P<0.5) in amount of total cholesterol, LDL, total protein, and albumin in experimental group by comparison with control group. But no significant differences were seen in the diameter of hepatocytes and their nuclei between both groups. The electromagnetic radiations of MRI device may influence the level of liver enzymes and liver function without any histomorphologically changes. Conducting clinical trial studies with human subjects is recommended.
